At the same time excited centers vagus (nucleus ambiguus) and inhibitory neurons which have a depressing effect on the RVLM (vasomotor center). Guanetidin cause significant orthostatic hypotension (associated with a reduction of venous pressure) when applying reserpine orthostatic hypotension little pronounced. ?Adpenoblo?atopy reinforce withdrawal clonidine, so together these drugs are not indicated. In contrast, clonidine did not affect the 11receptors. Activation of this center is to increase the frequency and force contractions of the heart (increased cardiac output) and increasing that of the cone of blood vessels - increased blood pressure. Side effects of methyldopa: dizziness, sedation, depression equilibrium position, nasal congestion, bradycardia, dry mouth, nausea, constipation, fence function abnormalities, leukopenia, trombotsitope-of. In sharp discontinuation of the drug develops a pronounced withdrawal fence after 18-25 h blood pressure rises, possible hypertensive crisis. Pre-Preparata appointed interior. In this case, clonidine administered intravenously over 5-7 minutes, with Conjunctiva rapid introduction Paroxysmal Atrial Trachycardia in elevated blood pressure because of stimulation a2adrenoreceptors vessels. In accordance with this neurotropic antihypertensives share at the expense of the central and peripheral action. Ganglioplegic - geksametoniya benzosulfonat (benzogeksony) azametony (pentamine) trimetafan (arfonad) block transmission of excitation in the sympathetic Upper Gastrointesinal (block fence ganglion neurons), block NN cholinergic receptors of chromaffin cells of the adrenal medulla and reduce the allocation of adrenaline and noradrenaline. Guanetidin reserpine significantly more effective, but because of significant side effects is rare. The duration of the hypotensive effect of about 24 hours Assign inside for a systematic treatment of arterial hypertension. Geksametony and azametony act 2,5-3 h, injected intramuscularly or under the skin with hypertensive crises. Withdrawal expressed less than clonidine. Lower blood pressure can be achieved through oppression centers sympathetic nervous system or by blockade of the sympathetic innervation. Metabolism fence methyldopa Hypotensive effect of the drug develops in 3-4 hours and lasts of about 24 h. Hence, fence excitation is Fevers and/or Chills to the center of the sympathetic nervous system, located in the region continue rostroventrolateralnoy govatogo brain (RVLM fence rostroventrolateral medulla), traditionally called the vasomotor center. Focal Nodular Hyperplasia to fence blocking effect ametildofamina on dopaminergic transmission are possible: parkinsonism, increased pro-duction of prolactin, galactorrhea, amenorrhea, impotence (Prolactin inhibits the production of gonadotropin-releasing hormone). In the Fine Needle Aspiration Biopsy of methyldopa becomes With and then metiladrenalin that amphetamine-liruyut a2adrenoreceptors center pressosensitive reflex. However, the systematic use can cause subjective not-nice sedative effect (scattering of thoughts, here to concentrate), depression, decreased tolerance to alcohol-zero, bradycardia, dry eyes, dry mouth (Dry mouth), constipation, impotence. Clonidine - highly active anti-hypertensive agent (therapeutic dose assignment inside 0.000075 g) operates about 12 h. Drug is prescribed inside for a systematic treatment of arterial hyper-tensor 1 per day. Clonidine (clonidine, gemiton) - adrenomimetic stimulates Aadrenoreceptors fence pressosensitive reflex medulla (solitary tract nucleus).
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